Analysis of N-Nitrosodimethylamine and N-Nitrosodiethylamine Using the Agilent 7697A Headspace Sampler, 8890/5977 GC/MSD System | LabRulez GCMS
 

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Application NotePharma & BiopharmaAnalysis of Five NitrosamineImpurities in Drug Products and DrugSubstances Using Agilent GC/MS/MSInstrumentationAuthorsSoma Dasgupta,Lalith Hansoge, Vivek Dhyani,Samir Vyas, andMelissa ChurleyAgilent Technologies, Inc.AbstractThis application note highlights a comprehensive solution for the determinationand estimation of five nitrosamine impurities (NDMA, NDEA,...
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relative, relativeresponses, responsesndba, ndbaneipa, neipandipa, ndipandma, ndmandea, ndeaotr, otrfda, fdastd, stdcounts, countsconcentration, concentrationacquisition, acquisitiondrug, drugimpurities
ApplicationNoteNo.62Analysis of Pharmaceuticals’ Impurity- Regulations and Analysis for Carcinogenic Substances Dheeraj Handique *a), Nitish Suryawanshi *a), Crystal Yeong *b), Cynthia Lahey *b), Shailendra Rane *a), Deepti Bhandarkar *a),Anant Lohar *a), Gao Jie san *c), Li Qiang *c), Fan Jun *c),...
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ndma, ndmandea, ndeacarcinogenic, carcinogenicsubstances, substancesmutagenic, mutagenicmms, mmsimpurity, impurityems, emsmode, modedrug, drugims, imsmutagenicity, mutagenicityolmesartan, olmesartanndba, ndbapharmaceuticals
Nitrosamine ImpuritiesApplication GuideConfidently Detect and QuantifyMutagenic Impurities in APIs andDrug Products Sartan-BasedLosartan ValsartanCandesartan TelmisartanMetforminRanitidineNitrosamines are formed by chemical reactions that occur during APImanufacturing whether from starting materials, intermediates, reactants, reuse ofsolvents and by-products; they can form through degradation products generatedduring formulation...
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back, backndma, ndmaneipa, neipafda, fdandipa, ndipandea, ndeandba, ndbametformin, metforminnitrosamine, nitrosamineintroduction, introductionapi, apibest, bestvalsartan, valsartancandesartan, candesartanquant
Nitrosamines Analysisin PharmaceuticalsUsing Single Quadrupole GC/MS or Triple Quadrupole GC/MSConsumables workflow ordering guideR1NNR2RO2R1RNN2R1ROR21NNNNO Mutagenic impurities in APIs and drug products pose a significant risk to health and safety—even in small quantities—and thus are a major concern for drug makers. Mutagenic impuritiescan...
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nitrosamine, nitrosaminenitrosamines, nitrosaminesndma, ndmandea, ndeamylist, mylistfavorite, favoriteneipa, neipandipa, ndipadrug, drugppm, ppmitems, itemsclick, clickinlet, inletreplacement, replacementyour
 

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Application NotePharma & BiopharmaAnalysis of Five NitrosamineImpurities in Drug Products and DrugSubstances Using Agilent GC/MS/MSInstrumentationAuthorsSoma Dasgupta,Lalith Hansoge, Vivek Dhyani,Samir Vyas, andMelissa ChurleyAgilent Technologies, Inc.AbstractThis application note highlights a comprehensive solution for the determinationand estimation of five nitrosamine impurities (NDMA, NDEA,...
Klíčová slova
relative, relativeresponses, responsesndba, ndbaneipa, neipandipa, ndipandma, ndmandea, ndeaotr, otrfda, fdastd, stdcounts, countsconcentration, concentrationacquisition, acquisitiondrug, drugimpurities
ApplicationNoteNo.62Analysis of Pharmaceuticals’ Impurity- Regulations and Analysis for Carcinogenic Substances Dheeraj Handique *a), Nitish Suryawanshi *a), Crystal Yeong *b), Cynthia Lahey *b), Shailendra Rane *a), Deepti Bhandarkar *a),Anant Lohar *a), Gao Jie san *c), Li Qiang *c), Fan Jun *c),...
Klíčová slova
ndma, ndmandea, ndeacarcinogenic, carcinogenicsubstances, substancesmutagenic, mutagenicmms, mmsimpurity, impurityems, emsmode, modedrug, drugims, imsmutagenicity, mutagenicityolmesartan, olmesartanndba, ndbapharmaceuticals
Nitrosamine ImpuritiesApplication GuideConfidently Detect and QuantifyMutagenic Impurities in APIs andDrug Products Sartan-BasedLosartan ValsartanCandesartan TelmisartanMetforminRanitidineNitrosamines are formed by chemical reactions that occur during APImanufacturing whether from starting materials, intermediates, reactants, reuse ofsolvents and by-products; they can form through degradation products generatedduring formulation...
Klíčová slova
back, backndma, ndmaneipa, neipafda, fdandipa, ndipandea, ndeandba, ndbametformin, metforminnitrosamine, nitrosamineintroduction, introductionapi, apibest, bestvalsartan, valsartancandesartan, candesartanquant
Nitrosamines Analysisin PharmaceuticalsUsing Single Quadrupole GC/MS or Triple Quadrupole GC/MSConsumables workflow ordering guideR1NNR2RO2R1RNN2R1ROR21NNNNO Mutagenic impurities in APIs and drug products pose a significant risk to health and safety—even in small quantities—and thus are a major concern for drug makers. Mutagenic impuritiescan...
Klíčová slova
nitrosamine, nitrosaminenitrosamines, nitrosaminesndma, ndmandea, ndeamylist, mylistfavorite, favoriteneipa, neipandipa, ndipadrug, drugppm, ppmitems, itemsclick, clickinlet, inletreplacement, replacementyour
 

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