Column selection and optimization for Solvent analysis

Column selection for solvents is basically is divided into 3 situations: Some want to replace an existing column and need a similar type to do the exact separation.

Here the challenge is to find the exact similar phase technology, which has become more difficult with the introduction of the proprietary “arylene” stabilized phases.

The other situation is that the user wants to improve the analysis. Here there are many different drivers for selecting a “different” column. This can be a shorter analysis time(cost per analysis) where shorter columns of similar ID will help out, but also smaller bore columns will allow us to maintain efficiency and reduce the run time. Some need a better separation, lower detection limits, need more robust solutions , eliminate column coupling or just have a longer column life time. Several examples will be shared.

The last situation is when user has a new application where one needs to develop a new method for. Here columns can be selected based on optimal dimensions and phase chemistries. To select the best possible phase one can now also use the ProEZGC chromatogram modeler and use this to select the phase with maximum resolution of target components.

Presenter: Jaap de Zeeuw