High-Throughput BTEX Analysis in Nail Products Using Solid Phase Microextraction (SPME) and Agilent GC/TQ: Minimal Steps, Maximum Precision

This webinar introduces a rapid headspace SPME method for quantifying BTEX in nail product matrices using the Agilent 8890 GC with a 7000 Series triple quadrupole MS (GC/TQ). Smart SPME technology enables solvent-free extraction and automated fiber tracking, while GC/TQ in dynamic multiple reaction monitoring (dMRM) mode delivers high sensitivity and selectivity. The method uses a 1-minute extraction at 40 °C and an ~11-minute total cycle time, achieving R² up to 0.999 with Avg. RF RSDs of 4–10% over 10–5,000 ng (m&p-xylenes 20–10,000 ng). Accuracy and precision were verified with LCS recoveries of 100–108% and ≤8% RSD. Attendees will learn how this streamlined workflow supports high-throughput analysis and regulatory monitoring.

Speaker: Dr. Amy Cuthbertson

Amy brings extensive expertise in analytical chemistry, earning her Ph.D. from the University of South Carolina studying disinfection byproducts with GC-MS. She has held research roles at the University of California Berkeley, the National Renewable Energy Laboratory (NREL), and the National Institute of Standards and Technology (NIST), working on projects ranging from chemical remediation and plastic upcycling to non-target analysis of emerging contaminants. In her current role at Agilent, Amy supports customers and teams with advanced GCMS applications, leveraging her experience in method development and mass spectrometry