Modernizing Nitrosamine Analysis with Advanced Electron Ionization

Presented here is the use of a novel advanced electron ionization (AEI) source in conjunction with GC triple quadrupole mass spectrometry to provide a simple way to measure nitrosamines at low part per trillion (ng/L, ppt) levels.

Nitrosamines are substances of increasing concern in relation to drinking water safety. As such, low level analysis of these challenging compounds is required. The main reference method (EPA 521) addresses this using a chemical ionization (CI) GC-MS/MS approach. However, the CI approach can present some challenges with routine analysis. Presented here is the use of a novel advanced electron ionization (AEI) source in conjunction with GC triple quadrupole mass spectrometry to provide a simple way to measure nitrosamines at low part per trillion (ng/L, ppt) levels as well as offering the opportunity to make significant method efficiencies during sample preparation.

Learning Objectives of Webinar

• Learn about the analysis of emerging drinking water contaminants such as nitrosamines which have the potential for future regulation and therefore requirement for testing in drinking water labs across the world.
• Learn about the advantages of GC-MS/MS technology for the analysis of nitrosamines in drinking water versus legacy chemical ionization and ion trap methods.
• Explore how the latest in GC-MS ion source technology enables opportunities to increase productivity in the routine laboratory.

Presenter: Maria José Farré, Research Scientist, Catalan Institute for Water Research (ICRA)

Maria José Farré is a research scientist at the Catalan Institute for Water Research (ICRA), Girona, Spain. Her research has focused on understanding oxidation mechanisms of contaminants, natural organic and inorganic matter during the treatment of drinking and wastewater. Her current scientific interests are related to the formation and fate of disinfection by-products (DBPs) as well as detection of DBP precursors during the production and transportation of both, drinking and high quality recycled water. Nitrogen-based such as NDMA, chlorinated, brominated and iodinated DBPs are included in her research plan as well as conventional and alternative disinfectants.

Presenter: Aaron Lamb, Senior Application Specialist, Thermo Fisher Scientific

Aaron is a Senior Mass Spectrometry Applications Specialist working in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific, Runcorn, UK. Aaron is an experienced analytical chemist and mass spectrometrist responsible for application method development using GC-MS technology, in particular single and triple quadrupole-based mass spectrometry. Aaron has also worked in industry as a R&D and Pharma Team Leader at Intertek gaining strong hands-on experience with GC-MS and LC-MS systems used to investigate trace chemicals in pharmaceutical and environmental samples.