Chromatography & Mass Spectrometry Product Reference Guide

Význam tématu

Chromatography and mass spectrometry are essential for modern analytical challenges in environmental, life sciences, food safety, pharmaceutical and industrial applications. Integrated solutions that cover sample preparation, separation, detection and data management enable laboratories to achieve high throughput, reproducible results and robust performance while controlling costs.

Cíle a přehled studie / článku

The aim of this reference guide is to present the combined Thermo Scientific and Dionex portfolio covering ion chromatography IC, liquid chromatography LC, gas chromatography GC, mass spectrometry MS, sample preparation, software and service support. It highlights how this integrated offering addresses diverse workflows from routine QA QC to advanced research.

Použitá metodika a instrumentace

• Liquid chromatography: UHPLC HPLC nano LC systems including UltiMate 3000 series, SpectraSYSTEM, Accela High Speed and EASY-nLC platforms with pumps, detectors, autosamplers, columns and Viper fittings
• Gas chromatography: compact and high performance GC, GC MS and GC MS MS instruments such as FOCUS, TRACE, ISQ, TSQ Quantum XLS and ITQ Series
• Mass spectrometry: triple quadrupole systems TSQ Quantum Ultra, TSQ Access MAX, TSQ Vantage; ion traps LCQ Fleet, LTQ Velos Pro; and high resolution Orbitrap based Exactive, Q Exactive, LTQ Orbitrap and Orbitrap Elite
• Ion chromatography: modular and compact RFIC systems ICS 5000, 2100, 1600, 1100, 900 with eluent generation, suppressors and IonPac columns
• Sample preparation: Accelerated Solvent Extraction ASE, AutoTrace SPE, automated on line SPE kits, Rocket Evaporator and specialized cartridges
• Chromatography software: Chromeleon, Atlas, ChromQuest, Xcalibur, DCMSLink; application specific modules for proteomics, metabolomics, pharmacokinetics, forensic screening and LIMS integration
• Service and support: installation, calibration, preventive maintenance, training and multi vendor support plans

Hlavní výsledky a diskuse

The integration of Dionex innovation in separations chemistry with Thermo Scientific strength in mass spectrometry and software yields a comprehensive portfolio. Key findings include:

• UHPLC systems achieve faster runs, improved resolution and reduced solvent consumption at accessible price points
• High resolution accurate mass Orbitrap platforms enable confident identification, quantification and fragment analysis in complex matrices
• Triple quadrupole and ion trap mass spectrometers support sensitive targeted quantification and structural elucidation workflows
• Competitive GC solutions address routine QC and demanding high throughput applications
• Reagent free ion chromatography simplifies IC workflows with on demand eluent generation and low background
• Automated sample preparation technologies enhance throughput, reduce manual steps and improve reproducibility
• Comprehensive software and LIMS integration streamline data handling, support regulatory compliance and facilitate lab automation

Přínosy a praktické využití metody

• Broad application range from environmental analysis to proteomics, metabolomics and food safety
• Modular system architectures allow flexible configuration and upgrades
• High productivity through parallelization and multiplexing in LC, MS and IC
• Reduced total cost of ownership via reagent free operation and predictive maintenance
• Improved data confidence with high resolution accurate mass and suppression technologies
• Seamless workflow integration from sample to report with software and service support

Budoucí trendy a možnosti využití

Expected developments include further miniaturization and ultrahigh throughput on one hand and increased sensitivity and selectivity on the other. Advances in data analytics, machine learning and cloud based laboratory informatics will drive more automated decision making. Green chemistry initiatives will promote solvent and energy reduction. Expansion of multiplexed assays and real time monitoring will open new frontiers in clinical and process analytics.

Závěr

The combined Thermo Scientific Dionex portfolio delivers end to end analytical solutions that meet the evolving needs of diverse laboratories. By coupling innovative separation technologies with leading mass spectrometry, software and service, one can achieve reliable, reproducible and high confidence results across a wide range of applications.

Reference

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