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Impurity Profiling of Pharmaceutical Starting Materials Using Gas Chromatography Coupled with High- Resolution Accurate Mass Spectrometry

 

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Dominic Roberts,1 Andrew Feilden,2 Richard Barlow,2 Kyle D’Silva,1 and Paul Silcock1 1 Thermo Fisher Scientific, Runcorn, UK 2 Smithers Rapra, Shawbury, UK Key Words Extractables and Leachables, Q Exactive GC, Orbitrap mass spectrometry, differential analysis, unknown identification, container closure system,…
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and accurate differential analysis to be performed to isolate unique features in extracts. Routine mass resolution of 60,000 FWHM and consistent sub-ppm mass accuracy ensures selective and confident compound detection and identification. POSTER NOTE Introduction The investigation of potentially toxic…
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Unique Benefits Delivered by Orbitrap GC Technology for Non-Targeted Analysis Jason Cole Orbitrap GC/MS Product Manager The world leader in serving science Presentation Overview • Thermo Scientific™ Orbitrap™ GC/MS Systems Overview • Orbitrap GC/MS System for Targeted Screening and Confirmation…
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Dominic Roberts1, Andrew Feilden2, Richard Barlow2, Jason Cole1, Alexander Semyonov1, Kyle D’Silva1, and Paul Silcock1 1 Thermo Fisher Scientific, Runcorn, UK; 2Smithers Rapra, Shawbury, UK. Poster Note 64741 Identification of Leachable Impurities from Pharmaceutical Container Closure Materials Using Orbitrap based…
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